Buy Tolperisone

The mechanism of action is not fully understood. Tolperisone has a high affinity for nervous tissue, reaching the highest concentrations in the brain stem, spinal cord and peripheral nervous system. The main effect of tolperisone is mediated by inhibition of the spinal reflex arcs. Probably, this effect, together with the elimination of the facilitation of the conduction of excitation along the descending pathways, provides the therapeutic effect of tolperisone. The chemical structure of tolperisone is similar to that of lidocaine. Like lidocaine, it has a membrane-stabilizing effect and reduces the electrical excitability of motor neurons and primary afferent fibers. Tolperisone dose-dependently inhibits the activity of voltage-gated sodium channels. Accordingly, the amplitude and frequency of the action potential decreases. An inhibitory effect on voltage-gated calcium channels has been proven. It is assumed that, in addition to its membrane-stabilizing action, tolperisone may also inhibit the release of the mediator. Tolperisone has some weak properties of α-adrenergic antagonists and antimuscarinic action.

It has a membrane stabilizing and local anesthetic effect, reduces pain sensitivity of peripheral nerve endings, inhibits impulse conduction in primary afferent and motor fibers, which leads to blocking of mono- and polysynaptic spinal reflexes. Probably, secondarily, due to inhibition of Ca2 + entry into the presynaptic endings, it inhibits the release of mediators in synapses. Promotes inhibition of the conduction of excitation along the reticulospinal pathway. Selectively reduces the activity of the caudal part of the reticular formation of the brain, reducing spasticity. Reduces pathologically increased muscle tone and muscle stiffness, reduces pain, facilitates voluntary active movements. It has weak antispasmodic and adrenergic blocking effects. Increases peripheral blood flow regardless of the influence of the central nervous system

• Treatment of pathologically increased muscle tone and spasms of striated muscles due to organic diseases of the central nervous system (including lesions of the pyramidal tract, multiple sclerosis, stroke, myelopathy, encephalomyelitis);
• treatment of increased tone and muscle spasms, muscle contractures accompanying diseases of the musculoskeletal system (including spondylosis, spondyloarthrosis, cervical and lumbar syndromes, arthrosis of large joints);
• rehabilitation treatment after orthopedic and traumatological operations;
• as part of the combined therapy of obliterating vascular diseases (obliterating atherosclerosis, diabetic angiopathy, thromboangiitis obliterans, Raynaud's disease), diseases arising from disorders of vascular innervation (acrocyanosis, intermittent angioedema);
• a specific pediatric indication is Little's disease (infantile cerebral palsy) and other encephalopathies with muscular dystonia - only for pills. 

There are indications that tolperisone has a vasodilating effect and can be used to relieve angiospasms, improve blood and lymph circulation, and also that the drug reduces the adhesive activity of platelets.

• Hypersensitivity (including to lidocaine - with parenteral administration);
• myasthenia gravis;
• children's age up to 1 year (tablets), children's age (parenteral administration)

Inside, after eating. Adults - usually starting with 50 mg 2-3 times a day, gradually increasing the dose to 150 mg 2-3 times a day; children - depending on age.

Usually Tolperisone is well tolerated. In some cases, a feeling of slight intoxication, headache, increased irritability, and sleep disturbances are possible. These phenomena disappear with a decrease in the dose or a temporary break in taking the drug.

Possible side effects are:

• Muscle weakness,
• headache,
• decreased blood pressure,
• nausea,
• vomiting,
• abdominal discomfort (usually disappear when the dose is reduced),
• in rare cases, allergic reactions (pruritus, erythema, urticaria, angioedema, anaphylactic shock, shortness of breath, bronchospasm)

Can be used in combination with sedatives, hypnotics and drugs containing alcohol. Does not affect the effect of alcohol on the central nervous system. Tolperisone enhances the effect of niflumic acid (with simultaneous use, a decrease in the dose of niflumic acid may be required). Drugs for general anesthesia, peripheral muscle relaxants, psychotropic drugs, clonidine - enhance the effect of tolperisone.

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We guarantee that you will receive your parcel with Tolperisone without any problems at customs (we have our own delivery channels to countries with strict customs).

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Due to Quarantine, delivery time may increase slightly, but still delivery remains within reasonable limits and does not exceed the delivery time during Christmas sales.

There is no prescription required!

You can legally buy Tolperisone on our website without prescription!