Buy Mildronate (Meldonium) 250 mg 40 capsules online.
Мanufacturer: Grindex
Country of origin: Latvia
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Buy Mildronate (Meldonium) 250mg N40
Pharmacological properties
Mildronate® - structural analog of gamma-butyrobetaine - a substance that is in every cell of the human body.
In high load conditions mildronat restores the balance between delivery and cellular oxygen demand, eliminating the accumulation of toxic products of metabolism in the cells, protecting them from damage and provides a tonic effect. As a result of its use of the body acquires the ability to withstand stress and to quickly restore energy reserves. Because of these properties mildronat used to treat a variety of disorders of the cardiovascular system, the blood supply to the brain, as well as to improve physical and mental performance. As a result of reducing the concentration of carnitine is synthesized hard gamma-butyrobetaine, which has vasodilating properties. In the case of acute ischemic myocardial injury, mildronat slows the formation of necrotic areas, shorten the rehabilitation period. In heart failure, increases myocardial contractility, increases exercise tolerance, reduces the frequency of angina attacks. In acute and chronic ischemic cerebrovascular disorders improves blood circulation in the ischemic focus, promotes redistribution of blood to the ischemic area. It is effective in the case of vascular and dystrophic pathology of the ocular fundus. The drug eliminates functional disturbances of the nervous system in patients with chronic alcoholism during abstinence syndrome.
Pharmacokinetics
After oral administration, the drug is rapidly absorbed, bioavailability - 78%. Maximum plasma concentration is achieved in 1-2 hours after administration. It is metabolized in the body into two major metabolites which the kidneys. The half-life when administered depends on the dose of 3-6 hours.
INDICATIONS
In the treatment of coronary heart disease (angina, myocardial infarction), congestive heart failure and cardiomyopathy dyshormonal, as well as in the treatment of acute and chronic disorders of the brain blood supply (cerebral strokes and cerebrovascular insufficiency).
Hemophthalmus and retinal hemorrhages of different etiologies, thrombosis of the central retinal vein and its branches, retinopathy of different etiology (diabetic, hypertensive).
Reduced working capacity; physical stress, including the athletes.
abstinence syndrome in chronic alcoholism (in combination with specific alcoholism therapy).
CONTRAINDICATIONS
Hypersensitivity to Mildronatu®, increased intracranial pressure (in violation of the venous outflow, intracranial tumors).
DOSAGE AND ADMINISTRATION
In view of the possible development of stimulating effect it is recommended to use in the morning.
1. Cardiovascular diseases. In the combined therapy of 0.5-1 g per day orally or intravenously (5.10 ml injection of 0.5 g / 5 ml), applying the entire dose at once or by dividing it by 2 times. The course of treatment - 4-6 weeks. Cardialgia on background dyshormonal myocardial dystrophy - inside of 0.25 g 2 times a day. The course of treatment - 12 days.
2. Violation of the cerebral circulation. Acute phase - 0,5 g 1 time per day intravenously for 10 days, moving to a reception inside of 0.5-1 g per day. The total course of treatment -4-6 weeks.
Chronic disorders - 0.5 g PO per day. The total course of treatment -4-6 weeks.
Repeated courses (usually 2-3 times a year) are possible after consultation with the doctor.
3. Vascular pathology and degenerative diseases of the retina. Parabulbarno 0.5 ml injection of 0.5 g / 5 ml for 10 days.
4. The mental and physical overload, including the athletes. Adults 0.25 g orally 4 times per day or 0.5 g intravenously 1 times a day. The course of treatment - 10-14 days. If necessary, the treatment is repeated after 2-3 weeks.
Athletes by 0.5-1 g orally 2 times a day before training. The duration of the preparatory period - 14-21 days, during the period of competition - 10-14 days.
5. Chronic alcoholism. Inside of 0.5 g 4 times a day; IV - 0.5 g 2 times per day. The course of treatment - 7-10 days.
SIDE EFFECT
Rarely - allergic reactions (redness, rash, itching, swelling), as well as dyspepsia, tachycardia, changes in blood pressure, agitation.
OVERDOSE
Cases mildronata overdose are not known. The drug has low toxicity and does not cause side effects that are dangerous to the health of patients.
INTERACTION WITH OTHER DRUGS
It increases the vasodilatig funds, some antihypertensive drugs, cardiac glycosides. It can be combined with antianginal drugs, anticoagulants, antiplatelet agents, antiarrhythmics, diuretics, bronchodilators. In view of the possible development of mild tachycardia and hypotension, caution should be exercised when combined with nitroglycerin, nifedipine, alpha-blockers, antihypertensive agents and peripheral vasodilators.
SPECIAL INSTRUCTIONS
Patients with chronic diseases of the liver and kidneys should be careful with long-term use of the drug.
There is insufficient data on the use mildronata children.
Many years of experience in the treatment of acute myocardial infarction and unstable angina in cardiology departments shows that trimethylhydrasine propionate dihydrate is not a first-line drug for acute coronary syndrome.
Use during pregnancy and lactation
The safety of the drug has not been proved during pregnancy.
To avoid possible adverse effects on the fetus during pregnancy, it is not prescribed.
It is not clear whether the drug is excreted in breast milk. If mildronate treatment for the mother is necessary, breast-feeding is stopped.
Effects on ability to drive and served by other mechanisms
No information about adverse effects on the reaction rate mildronata.
PACKAGING
10 capsules in blister. On 4 blisters with instruction on use in carton box.
The solution for injection in vials of 5 ml (0.5 g / 5 mL). 5 ampoules in a package of PVC film acheikova, 2 packings Valium together with instructions for use in a carton box.
SHELF LIFE
4 years. Do not use after the date printed on the packaging.
STORAGE CONDITIONS
The ampoules and capsules - at a temperature no higher than 25 ° C; capsule - in a dry place inaccessible to children.
The solution in the vials - do not freeze!