Buy Quetiapine

Quetiapine is an atypical antipsychotic drug. Quetiapine and its active metabolite N-desalkyl quetiapine interact with neurotransmitter receptors in the brain. Quetiapine and N-desalkyl quetiapine show high affinity for 5HT2 serotonin receptors and D1 and D2 dopamine receptors in the brain. Higher selectivity for serotonin receptors of the 5HT2 type than for dopamine D2 receptors determines the main clinical antipsychotic properties of Quetiapine-S3 and the low incidence of extrapyramidal side effects. In addition, N-desalkyl quetiapine exhibits a high affinity for the norepinephrine transporter. Quetiapine and N-desalkyl quetiapine have high affinity for histamine and α1-adrenergic receptors and less affinity for α2-adrenergic receptors and 5HT1 serotonin receptors. Quetiapine does not show significant affinity for cholinergic muscarinic and benzodiazepine receptors. In standard tests, quetiapine exhibits antipsychotic activity. The specific contribution of the N-desalkyl metabolite of quetiapine to the pharmacological activity of quetiapine has not been established. The results of the study of extrapyramidal symptoms (EPS) in animals revealed that quetiapine causes mild catalepsy at doses that effectively block D2 receptors. Quetiapine causes a selective decrease in the activity of mesolimbic A10 dopaminergic neurons in comparison with A9 nigrostriatal neurons involved in motor function.

• treatment of schizophrenia;
• treatment of manic episodes in the structure of bipolar disorder;
• treatment of depressive episodes from moderate to severe severity in the structure of bipolar disorder.
• Quetiapine in combination with mood stabilizers prevents recurrence of manic and depressive episodes in bipolar type I disorder; the risk of developing an episode of depression is especially pronounced.

According to some estimates, quetiapine is the most favorable drug among atypical antipsychotics in terms of safety. The most common reported effects are:

• sedation,
• drowsiness,
• orthostatic hypotension,
• dizziness,
• dyspepsia.

List of possible side effects

On the part of the body as a whole:

• headache,
• asthenia,
• abdominal pain,
• back pain,
• weight gain,
• fever,
• chest pain.

From the side of the central nervous system:

• drowsiness,
• dizziness,
• anxiety,
• extrapyramidal disorders.

From the side of the cardiovascular system:

• orthostatic hypotension,
• tachycardia,
• arterial hypertension.

From the digestive system:

• constipation,
• dry mouth,
• dyspepsia,
• diarrhea,
• increased activity of hepatic transaminases (ALT 6.1%, AST 3.5%, GGT 1.6%), which spontaneously returned to baseline with continued quetiapine therapy.

On the part of the hematopoietic organs:

• asymptomatic leukopenia and / or neutropenia;
• rarely - eosinophilia.

From the musculoskeletal system:

• myalgia.

From the respiratory system:

• rhinitis.

On the part of the skin:

• rash,
• dry skin.

On the part of the organ of hearing:

pain in the ear.

From the urinary system:

• diseases of the urinary tract,
• urinary tract of the country.

In addition, there have been cases of malignant manifestations of neuroleptic syndrome while taking quetiapine.

During treatment with quetiapine, there is a significant increase in serum cholesterol and triglycerides.

During treatment with quetiapine, there is a slight dose-dependent decrease in the level of thyroid hormones, in particular, and common T4. The maximum reduction in the prevalence and free T4 encephalopathy at the 2nd and 4th weeks of quetiapine therapy without long-term monitoring of hormone levels. There were no signs of significant changes in the detection of thyroid-stimulating hormone. In almost all cases, total and free T4 levels return to baseline after initiation of quetiapine therapy, regardless of the duration of treatment.

Quetiapine, like other antipsychotics, can prolong the QT interval, but this finding did not show an association between quetiapine and QT interval prolongation.

Hypersensitivity to any of the components of the drug.

Contraindications:

• Diseases of the hematopoietic system (both now and in the past),
• diabetes mellitus,
• impaired liver and kidney function,
• hyperthyroidism.

Concomitant use with cytochrome P450 3A4 inhibitors such as HIV protease inhibitors, azole antifungals, erythromycin, clarithromycin and nefazodone.

Use during pregnancy and breastfeeding.

Studies on the safety and efficacy of quetiapine in pregnant women have not been conducted. Thus, quetiapine should only be used during pregnancy if the expected benefit justifies the potential risk.

The extent to which quetiapine is secreted into human milk is not known.

If it is necessary to prescribe quetiapine during lactation, breastfeeding should be discontinued. In experimental studies, no mutagenic, clastogenic or teratogenic effects of quetiapine have been identified.

In experimental studies on animals, the effect of quetiapine on fertility was revealed (decrease in male fertility, pseudopregnancy, increase in the period between two estrus, increase in the precoital interval and decrease in the frequency of pregnancy), however, the data obtained cannot be directly transferred to humans, since there are specific differences in hormonal reproduction control.

Consult your doctor before use!

Adults:

Acute and chronic psychoses, including schizophrenia.

The daily dose for the first 4 days of therapy is: 1st day - 50 mg, 2nd day - 100 mg, 3rd day - 200 mg, 4th day - 300 mg. Starting on day 4, the dose should be adjusted to a clinically effective dose, which is usually in the range of 300 to 450 mg/day. Depending on the clinical effect and individual tolerability, the dose may vary from 150 to 750 mg / day.

Treatment of manic episodes in the structure of bipolar disorder.

Quetiapine is used as monotherapy or as adjuvant therapy for mood stabilization. The daily dose for the first 4 days of therapy is: 1st day - 100 mg, 2nd day - 200 mg, 3rd day - 300 mg, 4th day - 400 mg. In the future, by the 6th day of therapy, the daily dose of the drug can be increased to 800 mg. An increase in the daily dose should not exceed 200 mg per day. Depending on the clinical effect and individual tolerance, the dose may vary from 200 to 800 mg / day. Usually an effective dose is from 400 to 800 mg / day.

For the treatment of schizophrenia, the maximum recommended daily dose of quetiapine is 750 mg, for the treatment of manic episodes in the structure of bipolar disorder, the maximum recommended daily dose of quetiapine is 800 mg / day. 

Special patient groups

Elderly age.

In elderly patients, the initial dose of Quetiapine is 25 mg / day. The dose should be increased daily by 25–50 mg until an effective dose is reached, which is likely to be less than in younger patients.

Renal failure.

Dose adjustment is not required.

Liver failure.

Quetiapine is extensively metabolized in the liver. Therefore, caution should be exercised when using Quetiapine in patients with hepatic insufficiency, especially at the beginning of therapy. It is recommended to start therapy with Quetiapine at a dose of 25 mg / day and increase the dose daily by 25-50 mg until an effective one is achieved.

Quetiapine does not affect the pharmacokinetics of lithium.

The drug does not affect the metabolism of antipyrine.

With the simultaneous use of quetiapine and phenytoin (or other liver enzyme inducers, such as carbamazepine, barbiturates, rifampicin), an increase in the dose of quetiapine may be required. While a dose reduction may be required when phenytoin is canceled and replaced with a drug that does not induce microsomal liver enzymes (for example, sodium valproate).

However, the simultaneous use of quetiapine and thioridazine leads to an increase in the clearance of quetiapine.

Co-administration of quetiapine and antidepressants: imipramine or fluoxetine did not significantly affect the pharmacokinetics of quetiapine.

Caution is advised when using quetiapine concurrently with systemic use of potential CYP3A4 inhibitors (such as ketoconazole or erythromycin).

With a single dose of 2 mg of lorazepam while taking quetiapine at a dose of 250 mg 2 times a day, the clearance of lorazepam is reduced by about 20%.

Quetiapine reduces the effect of levodopa and dopamine agonists.

False-positive screening tests for methadone and tricyclic antidepressants by enzyme immunoassay have been reported in patients taking quetiapine. Chromatography is recommended to confirm screening results.

Caution should be exercised when used with other drugs that affect the central nervous system, as well as with alcohol.

Grapefruit juice is not recommended during quetiapine therapy.

You can buy Quetiapine from our website absolutely legally.

Delivery is carried out to all countries in the world, which do not have an official ban on receiving and sending mail (mainly island countries).

We guarantee that you will receive your parcel with Quetiapine without any problems at customs (we have our own delivery channels to countries with strict customs).

We guarantee a refund if your package has not been delivered to you for any reason, according to PayPal protection policy.

Due to Quarantine, delivery time may increase slightly, but still delivery remains within reasonable limits and does not exceed the delivery time during Christmas sales.

There is no prescription required!

You can legally buy Quetiapine our website without prescription! 

High doses or long-term use of quetiapine can cause a serious movement disorder that may not be reversible. The longer you use quetiapine, the more likely you are to develop this disorder, especially if you are an older adult. Symptoms of this disorder include tremors or other uncontrollable muscle movements.

An overdose of quetiapine can be fatal.

When treating with quetiapine, it is undesirable to perform work that requires a quick reaction; the consumption of alcoholic beverages is also not recommended.

At the beginning of quetiapine therapy, it is recommended to slowly increase the dose due to the risk of transient increase in liver enzymes, the possibility of dizziness and orthostatic hypotension.