Buy Klenzit (Klenzit-C, Klenzit-C microspheres)

Klenzit has a high lipophilicity. When applied topically, it easily penetrates the hair follicles and is absorbed 5 minutes after topical application. After penetration into the follicle, adapalene binds to nuclear retinoic acid receptors. These complexes then bind to the retinoid X receptor, which induces gene transcription by binding to specific DNA regions, thus modulating the proliferation and differentiation of keratinocytes. This leads to a normalization of keratinocyte differentiation, which allows to reduce the formation of microcomedones, reduce clogging of pores and increase exfoliation by increasing cell turnover.

Adapalene is also regarded as an anti-inflammatory agent, as it inhibits the stimulated inflammatory response in the presence of Cutibacterium acnes,and inhibits both lipoxygenase activity and the oxidative metabolism of arachidonic acid to prostaglandins.

Adapalene selectively targets the retinoic acid receptor beta and retinoic acid receptor gamma when applied to epithelial cells such as skin cells.Its gamma subtype agonism is largely responsible for the observed effects of adapalene. In fact, when adapalene is used in combination with a retinoic acid receptor gamma antagonist, adapalene loses clinical efficacy.

Retination is a common temporary phenomenon reported by patients when starting to use retinols. During the initial period of treatment, the skin may become red, irritated, dry, and may burn or itch from the use of retinol; however, it tends to resolve within four weeks when used once a day.

According to the Global Acne Outcomes Alliance guidelines, retinoids such as adapalene are considered first-line treatment for acne and should be used either alone or in combination with benzoyl peroxide and/or an antimicrobial agent such as clindamycin for maximum effectiveness. In addition, adapalene, like other retinoids, increases the effectiveness and penetration of other topical acne medications that are used in combination with topical retinoids, as well as hastening the improvement of post-inflammatory hyperpigmentation caused by acne. In the long term, it can be used as maintenance therapy.

From the senses: burning sensation in the eyes, irritation of the eyelids, itching of the eyelids, swelling of the eyelids, erythema in the eyelids;

from the digestive system for drug with Clindamycin: abdominal pain, gastrointestinal disorders (diarrhea, nausea, vomiting);

on the part of the skin: erythema, dryness and peeling of the skin, itching, burning, skin irritation, tingling, increased acne, contact dermatitis, increased production of sebaceous glands, urticaria, allergic reactions, sunburn (photosensitization) at the site of application of the drug, a feeling of discomfort , soreness of the skin, swelling of the skin;

others: folliculitis caused by gram-negative flora; In rare cases, colitis may develop.

Contraindications

• Hypersensitivity to the components of the drug;
• Simultaneous use with drugs containing erythromycin;
• Pregnancy;
• The period of lactation;
• Klenzit is not recommended for use in children under the age of 18 years (data on efficacy and safety are not available).

Outwardly. Before applying the gel, clean and dry the skin. With a light touch, evenly apply the gel to the affected areas of the skin once a day before going to bed, avoiding contact with the eyes, lips and other mucous membranes. The therapeutic effect develops in 1-4 weeks, the course of therapy is 4-8 weeks. A second course of treatment is possible after consultation with a doctor. If skin irritation occurs, treatment should be suspended until signs of irritation disappear.

The drug should not be used simultaneously with other retinoids or antibiotics for external use, or drugs with a similar mechanism of action. Since adapalene can cause local skin irritation in some patients, in order to avoid a cumulative effect, simultaneous use with other products that have a drying or irritating effect is not recommended (medical or abrasive soaps and detergents; soaps and cosmetics with a drying effect; perfumes, ethanol-containing products and etc.).

Caution should be exercised when combined with drugs that have an irritating or drying effect, including those containing sulfur, resorcinol or salicylic acid (possibly increased side effects).

Shows antagonism with erythromycin. Since systemic absorption of the drug when applied externally is negligible, any drug interactions with drugs used systemically are unlikely.

There is cross-resistance of microorganisms to clindamycin and lincomycin. It has been established that clindamycin disrupts neuromuscular transmission and, therefore, may enhance the effect of other peripherally acting muscle relaxants, so the drug should be used with caution in patients receiving drugs of this group.

You can buy Klenzit from our website absolutely legally.

Delivery is carried out to all countries in the world, which do not have an official ban on receiving and sending mail (mainly island countries).

We guarantee that you will receive your parcel with Klenzit without any problems at customs (we have our own delivery channels to countries with strict customs).

We guarantee a refund if your package has not been delivered to you for any reason, according to PayPal protection policy.

Due to Quarantine, delivery time may increase slightly, but still delivery remains within reasonable limits and does not exceed the delivery time during Christmas sales.

There is no prescription required!

You can legally buy Klenzit our website without prescription! 

With caution: dermatitis, eczema, allergic diseases, simultaneous use of muscle relaxants, simultaneous use of drugs that irritate or dry the skin. If you have one of the listed diseases, be sure to consult your doctor.

During pregnancy and lactation, the use of the drug is contraindicated.

Excessive application of the gel does not lead to a faster or better result, at the same time, pronounced skin reactions may occur - redness, peeling.

Avoid getting the drug on the mucous membrane of the eyes and in the oral cavity.

Wash your hands thoroughly after using the drug. In case of accidental contact with sensitive surfaces (eyes, mucous membranes, skin lesions), rinse the area with plenty of water.

In case of allergic reactions or severe irritation, the use of the drug should be discontinued. The drug is not used in the presence of skin lesions, eczema, as well as in patients with severe acne and when large areas of the body surface are affected.

Avoid direct sunlight, because. skin irritation may occur. In case of prolonged exposure to the sun, do not apply the gel the day before, as well as on the day of sun exposure and the following day.

With external use of clindamycin, cases of diarrhea and colitis are rare, however, caution should be exercised, and if severe or prolonged diarrhea develops, the drug should be discontinued and, if necessary, appropriate diagnostic and therapeutic measures should be taken.