Buy Ketorolac

The mechanism of action is associated with non-selective inhibition of the activity of cyclooxygenase 1 and cyclooxygenase 2, which catalyzes the formation of prostaglandins from arachidonic acid, which play an important role in the pathogenesis of pain, inflammation and fever. The strength of the analgesic effect is comparable to morphine, significantly superior to other NSAIDs. After intramuscular injection, the onset of analgesic action is noted after 0.5 hours, the maximum effect is achieved after 1-2 hours.

Pain syndrome of strong and moderate severity:

• injuries,
• toothache,
• pain in the postpartum and postoperative period,
• cancer,
• myalgia,
• arthralgia,
• neuralgia,
• sciatica,
• dislocations,
• sprains,
• rheumatic diseases.

It is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

From the digestive system: often - gastralgia, diarrhea; less often - stomatitis, flatulence, constipation, vomiting, feeling of fullness in the stomach; rarely - loss of appetite, nausea, erosive and ulcerative lesions of the gastrointestinal tract (including with perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, blood in the stool or melena, vomiting with blood or type "coffee grounds", nausea, heartburn, etc.), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.

From the urinary system: rarely - acute renal failure, back pain, hematuria, azotemia, hemolytic uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), increased urination, increase or decrease in urine volume, nephritis, edema of renal origin. sensory organs: rarely - hearing loss, tinnitus, visual impairment (including blurred vision).

From the sensory organs: rarely - hearing loss, ringing in the ears, visual impairment (including blurred vision).

From the respiratory system: rarely - bronchospasm or dyspnea, rhinitis, pulmonary edema, laryngeal edema (shortness of breath, difficulty breathing ).

From the side of the central nervous system: often - headache, dizziness, drowsiness, rarely - aseptic meningitis (fever, severe headache, convulsions, neck and / or back muscle stiffness), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis.

From the side of the cardiovascular system: less often - an increase in blood pressure.

From the side of the hematopoietic organs: rarely - anemia, eosinophilia, leukopenia.

From the side of the hemostasis system: rarely - bleeding from a postoperative wound, epistaxis, rectal bleeding.

Sides of the skin: less often - skin rash (including maculopapular rash), purpura, rarely - exfoliative dermatitis (fever with or without chills, hyperemia, thickening or peeling of the skin, enlargement and / or soreness of the palatine tonsils), urticaria, malignant exudative erythema ( Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).

Local reactions: less often - burning or pain at the injection site.

Allergic reactions: rarely - anaphylaxis or anaphylactoid reactions (discoloration of the skin of the face, skin rash, urticaria, skin itching, tachypnea or dyspnea, eyelid edema, periorbital edema, shortness of breath, shortness of breath, heaviness in the chest cage, wheezing).

Others: often - edema (face, shins, ankles, fingers, feet, weight gain); less often - increased sweating, rarely - swelling of the tongue, fever.

• complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history);
• urticaria, rhinitis caused by taking NSAIDs (history);
• intolerance to drugs of the pyrazolone series;
• dehydration, hypovolemia (regardless of the cause that caused it);
• bleeding or a high risk of their development;
• condition after coronary artery bypass grafting; confirmed hyperkalemia;
• inflammatory bowel disease;
• erosive and ulcerative lesions of the gastrointestinal tract in the acute stage, peptic ulcers;
• hypocoagulation (including hemophilia);
• severe renal failure (CC less than 30 ml / min);
• severe liver failure or active liver disease;
• hemorrhagic stroke (confirmed or suspected);
• hemorrhagic diathesis;
• violation of hematopoiesis;
• pregnancy;
• childbirth;
• lactation period (breastfeeding);
• children under 16 years of age (efficacy and safety have not been established);
• hypersensitivity to ketorolac and other NSAIDs.

The drug is not used as a means for premedication, maintenance anesthesia, pain relief before and during surgical operations (including in obstetric practice) due to the high risk of bleeding.

The drug is not indicated for the treatment of chronic pain.

With caution:

• bronchial asthma;
• cholecystitis;
• chronic heart failure;
• arterial hypertension;
• impaired renal function (plasma creatinine below 50 mg / l);
• cholestasis;
• active hepatitis;
• sepsis;
• systemic lupus erythematosus;
• old age (over 65 years);
• polyps of the nasal mucosa and nasopharynx, concomitant use with other NSAIDs;
• the presence of factors that increase the toxicity of the gastrointestinal tract: alcoholism, smoking;
• postoperative period,
• edematous syndrome,
• ischemic heart disease,
• cerebrovascular disease,
• dyslipidemia/hyperlipidemia,
• diabetes mellitus,
• peripheral arterial disease,
• creatinine clearance less than 60 ml/min,
• history of ulcerative lesions of the gastrointestinal tract, presence of Heliсobacter pylori infection,
• long-term use of NSAIDs,
• severe somatic diseases,
• simultaneous oral corticosteroids (including prednisolone), anticoagulants (including warfarin),
• antiplatelet agents (including clopidogrel),
• selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) ).

Inside, intramuscularly, intravenously. In children, only by injection. The dose is selected individually, taking into account the severity of the pain syndrome. A single dose is 10–30 mg, the frequency of administration is up to 4 times a day (every 6–8 hours). The maximum daily dose for elderly patients is 60 mg. The solution is prescribed intramuscularly or intravenously for the treatment of acute and severe pain for no more than 5 days, in children - 2 days. Tablets are used no more than 5-7 days.

When combined with other NSAIDs, fluid retention, cardiac decompensation, and arterial hypertension may occur. To reduce the risk of developing NSAID-gastropathy, antacids, misoprostol, omeprazole are prescribed.

The effect on platelet aggregation persists for 24-48 hours.

Hypovolemia increases the risk of adverse reactions from the kidneys.

If necessary, it can be prescribed in combination with opioid analgesics.

Do not use simultaneously with paracetamol for more than 5 days.

Patients with impaired blood coagulation are prescribed the drug only with constant monitoring of the number of platelets, especially in the postoperative period, requiring careful monitoring of hemostasis.

Influence on the ability to drive vehicles and mechanisms

Since a significant part of patients with the appointment of Ketorolac develop side effects from the central nervous system (drowsiness, dizziness, headache), it is recommended to avoid performing work that requires increased attention and quick response (driving vehicles, working with mechanisms).

You can buy Ketorolac from our website absolutely legally.

Delivery is carried out to all countries in the world, which do not have an official ban on receiving and sending mail (mainly island countries).

We guarantee that you will receive your parcel with Ketorolac without any problems at customs (we have our own delivery channels to countries with strict customs).

We guarantee a refund if your package has not been delivered to you for any reason, according to PayPal protection policy.

Due to Quarantine, delivery time may increase slightly, but still delivery remains within reasonable limits and does not exceed the delivery time during Christmas sales.

There is no prescription required!

You can legally buy Ketorolac our website without prescription! 

• Reception with other NSAIDs, glucocorticosteroids, ethanol, corticotropin, calcium preparations increases the risk of ulceration of the mucous membrane of the gastrointestinal tract and the development of gastrointestinal bleeding.
• Simultaneous administration with anticoagulant drugs - coumarin and indandione derivatives, heparin, thrombolytics (alteplase, streptokinase, urokinase), antiplatelet drugs, cephalosporins, valproic acid and acetylsalicylic acid increases the risk of bleeding.
• Reduces the effect of antihypertensive and diuretic drugs (reduces the synthesis of prostaglandins in the kidneys). Appointment together with methotrexate increases hepato- and nephrotoxicity (their joint appointment is possible only when using low doses of the latter and controlling its concentration in plasma).
• When Ketorolac is administered with other nephrotoxic drugs (including gold preparations), the risk of developing nephrotoxicity increases.
• Drugs that block tubular secretion reduce the clearance of ketorolac and increase its plasma concentration.
• Increases the effect of narcotic analgesics.
• Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.