Most side effects of Acnecutan (Isotretinion) depend on the dose. Usually the side effects are reversible after the dose adjustment or drug withdrawal, but some may persist after the treatment is discontinued.
Symptoms associated with hypervitaminosis A: dry skin, mucous membranes, including lips (heilitis), nasal cavity (bleeding), larynx and pharynx (hoarseness of voice), eyes (conjunctivitis, reversible corneal opacity and contact lens intolerance).
Skin and its appendages: palm and soles peeling, rash, itching, facial erythema/dermatitis, sweating, pyogenic granuloma, paronichia, onychodystrophy, increased granular tissue growth, persistent thinning of hair, reversible hair loss, fulminant forms of acne, hirsutism, hyperpigmentation, photosensitization, mild skin trauma.
Musculoskeletal system: muscle pain, joint pain, hyperostosis, arthritis, calcification of ligaments and tendons, tendinitis.
CNS and the mental sphere: excessive fatigue, headache, increased intracranial pressure (pseudo brain tumor: headache, nausea, vomiting, visual impairment, swelling of the optic nerve), convulsive seizures, rarely - depression, psychosis, suicidal thoughts.
Senses: xerophthalmia, isolated cases of visual acuity disturbance, photophobia, dark adaptation disturbance; seldom - color perception disorders (occurring after the drug withdrawal), lenticular cataract, keratitis, blepharitis, conjunctivitis, eye irritation, optic neuritis, optic nerve edema; hearing impairment at certain sound frequencies, difficulties in wearing contact lenses.
GIT: dry mucous membrane of the mouth, bleeding gums, gum inflammation, nausea, diarrhea, inflammatory bowel disease (colitis, ileitis), bleeding, pancreatitis (especially in the associated hypertriglyceridemia - above 800 mg / dl).
Respiratory organs: rarely - bronchospasm (more often in patients with bronchial asthma in the history).
Blood system: anemia, reduction of hematocrit, leukopenia, neutropenia, increase or decrease of platelet count, SCE acceleration.
Laboratory indicators: hypertriglyceridemia, hypercholesterolemia, hyperuricemia, reduction of HDL; rarely - hyperglycemia. Cases of first detected diabetes have been registered during administration of the preparation Acnecutan.
Immune system: local or systemic infections caused by gram-positive agents (Staphylococcus aureus).
Others: lymphadenopathy, hematuria, proteinuria, vasculitis, systemic hypersensitivity reactions, glomerulonephritis.