
Buy Roaccutane (Sotret) online. PayPal
Active ingredient: Isotretinoin.
Analogues:
Accutane, Acnecutan, Absorica, Accutin, Actaven, Aknenormin...
Pharmacological group: Dermatotropic drug.
Roaccutane is the most famous medicine for treatment of severe forms of acne. Isotretinoin (Roaccutane) is the most effective drug for the treatment of moderate to severe acne, which, when used systematically, causes prolonged remission or cure in most cases. Development of Roaccutane was awarded the Galen Prize (analog of the Nobel Prize in pharmacology).
Country of manufacture: Germany/Switzerland.
Manufacturer: Catalent Germany Eberbach GmbH / F. Hoffmann-La Roche AG.
Form of release: 30 Capsules 10mg or 20mg.
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Buy Roaccutane
Roaccutane is prescribed in case of:
- severe acne;
- precancerous skin conditions and certain types of skin cancer;
- pink eels (rosacea);
- acne, which is not treatable in other ways.
Roaccutane with isotretinoin as the main ingredient is an effective treatment for acne, even in case of severe course of the disease.
Roaccutane is one of the types of vitamin A, the preparation performs a number of protective, restorative functions.
Multiple clinical trials have shown that the course of treatment can significantly reduce the number of acne due to its dependence on sebaceous glands. As is known, the main pathogenesis of acne is hyper-secreting and hyperplasia of sebaceous glands and increased kerato-education of the face skin, which is why black dots - camedones - appear.
Roaccutane blocks this process, thus normalizing salivation, improving its evacuation from the sebaceous glands ducts. Also, the drug improves the division of normal cells of the epithelium, their final differentiation.
Thus, Roaccutane affects several pathophysiological processes of acne. The drug helps in severe cases, when other methods of treatment are not effective.
For ichthyosis, pink acne and other diseases included in the list of indications, Roaccutane acts as a regenerating agent, helping the skin to recover.
Inside, during the meal, 1 or 2 times a day.
Standard dosing regime
Roaccutane treatment should start with a dose of 0.5 mg/kg/day. For most patients the dose varies from 0.5 to 1 mg/kg of body weight per day. Patients with very severe forms of disease or acne in the body may require higher daily doses - up to 2 mg/kg.
Full remission of acne is often achieved in 16-24 weeks of treatment.
In patients with very poor tolerance of the recommended dose, treatment can be continued at a lower dose but for longer periods.
Special cases
For patients with severe renal failure, treatment should be started at a lower dose (e.g. 10 mg/day) and then increased to 1 mg/kg/day or maximum tolerated.
With an apparent recurrence, a second course of Roaccutane treatment is shown in the same daily and course dose as the first. Since the improvement can continue up to 8 weeks after the drug withdrawal, the repeated course of treatment should not be started before the end of this period.
Roaccutane does not have a large list of contraindications.
- liver insufficiency;
- hypervitaminosis A;
- severe hyperlipidemia;
- complementary therapy with tetracyclines;
- pregnancy and lactation period;
- age under 12 years;
- hypersensitivity to the drug or its components.
Roaccutane should be taken with caution in case of: depression in the history, diabetes, obesity, lipid metabolism disorder, alcoholism.
The overdose of Roaccutane is similar to vitamin A hypervitaminosis.
To relieve the condition it is necessary to urgently wash the stomach, cancel the drug, and provide infusion therapy to detoxify the body.
Typical symptoms of overdose and vitamin A hypervitaminosis are:
- nausea, vomiting, abdominal pain;
- severe headache;
- pains in bones and joints;
- redness of the face skin and a burning and itchy feeling;
- xerostomia and dry skin.
One of the dangerous symptoms is acute liver failure, which is characterized by a violation of blood clotting. The liver and spleen are enlarged in size, pain appears on palpation. In such cases, it is necessary to immediately ask for medical care and to stop taking the medication.
Most side effects of Roaccutane are dose-dependent. Most side effects of Roaccutane are dose-dependent. As a rule, when administered the recommended doses, the benefit/risk ratio, given the severity of the disease, is reasonable for the patient. Usually, the side effects are reversible after a dose adjustment or drug withdrawal, but some may remain after discontinuation of therapy.
CNS and mental sphere: behavioral disorders, depression, headache, increased intracranial pressure, convulsive seizures.
Senses: individual cases of visual acuity disorder, photophobia, twilight vision acuity reduction, rarely - color perception disorder (occurring after the drug withdrawal), lenticular cataract, keratitis, blepharitis, conjunctivitis, eye irritation, optic nerve swelling (as a manifestation of intracranial hypertension); hearing impairment at certain sound frequencies.
Digestive system: nausea, diarrhea, inflammatory bowel disease (colitis, ileitis), bleeding; pancreatitis (especially with associated hypertriglyceridemia above 800 mg/dL). Rare cases of pancreatitis with fatal outcome have been described. Transient and reversible increase in the activity of hepatic transaminases, some cases of hepatitis.
In many of these cases, the changes did not go beyond the norm and returned to the initial parameters in the course of treatment.
Active ingredient: Isotretinoin 10mg or 20mg.
Auxiliary substances: soybean oil; beeswax yellow; hydrogenated soybean oil; partially hydrogenated soybean oil.
Capsule shell: gelatine; glycerol; Carion 83 (potato hydrolyzed starch, mannitol, sorbitol); cantaxanthin; titanium dioxide; capsule ink (shellac, iron oxide black dye)
No. Pregnancy and breastfeeding period are the main contraindications to Roaccutane use.
It is safe to get pregnant one month after taking the last Roaccutane capsule.
Yes, the drugs are interchangeable, as they contain the same active substance.
Capsule 20 mg Roaccutane = Capsule 16 mg Acnecutan.
Medications with which the effectiveness of Roaccutane decreases - antibiotics from the group of tetracyclines.
In order to avoid the risk of vitamin A hypervitaminosis, it is necessary to discontinue the use of all drugs that contain retinol.
Donors should stop the procedure of blood donation for the duration of treatment with Roaccutane and within 30 days after the end of it.
Wearing contact lenses should be avoided if there is sensitivity to light and side effects from the side of eyes.
In rare cases in the beginning of therapy there is an exacerbation of acne, which takes place within 7-10 days without correction of the drug dose.
Patients receiving Roaccutane are advised to use a moisturizing ointment or body cream, lip balm to reduce dry skin and mucous membranes at the beginning of therapy.
Women during treatment with Roaccutane should use reliable contraceptives, preferably oral contraceptives.
Sunbeds, sunbathing, waxing should be avoided during the treatment with Roaccutane.
Unlike many other antiacute drugs, which develop their full effect after a few weeks, Roaccutane usually starts to work quite quickly. Already on the first or second week of intake there is a significant reduction in seborrhea, by the end of the first or second month - a decrease in inflammation in the face and trunk, regression of comedones, after 3-8 months there will be a full recovery.
Roaccutane can be considered a safe drug. All its side effects are predictable and can be easily and effectively eliminated, with most side effects depending on the dose. Typically, when administered the recommended doses, the benefits of using Roaccutane in any group of patients, given the severity of the disease, far exceed the risk that Roaccutane may cause.
In a place protected from light and moisture, at a temperature not exceeding 25°C.
Keep out of the reach of children.
Shelf life: 3 years.
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