Buy Kaletra online. PayPal
Active ingredient: Lopinavir + Ritonavir.
Pharmacological group: Antiviral HIV medication.
Kaletra is a prescription medicine that is used with other antiretroviral medicines to treat human immunodeficiency virus-1 (HIV-1) infection in adults and children 14 days of age and older. It combines Lopinavir with a low dose of Ritonavir. HIV is the virus that causes AIDS (acquired immune deficiency syndrome). Kaletra may be used for prevention after a needlestick injury or other potential exposure.
Other brand names:
Aluvia, Ritocom
Manufacturer:
Abbott GmbH and Co.KG, Germany. 67061, Ludwigshafen, Knollstrasse 50, Germany.
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Buy Kaletra
For acquired human immunodeficiency syndrome (HIV infection) in adults and children from 3 years in combination therapy.
Inside, regardless of the food intake. Kaletra tablets should be swallowed entirely without chewing, breaking or shredding.
- The recommended dose of Kaletra 200/50 mg tablet is 400/100 mg (2 tablets) twice a day.
- 800/200 mg (4 tablets) once a day for patients with no more than two mutations associated with the development of resistance to lopinavir.
Children
- For children with body weight less than 35 kg and a body surface area of 0.6 m2 to 1.4 m2, it is recommended to use Kaletra tablets 100 mg + 25 mg;
- for children with body surface area less than 0.6 m2 or younger than 3 years of age there is a preparation Kaletra in the form of a solution for oral administration of 80 mg + 20 mg/ml.
- children from 6 months to 3 years of age are prescribed a medicine in the form of "solution for ingestion".
Currently, clinical experience with acute lopinavir/ritonavir overdose in humans is limited. There is no specific antidote. Treatment consists of activities aimed at sustaining the body's life support, including controlling vital systems and monitoring the clinical condition of the patient.
- Hypersensitivity to lopinavir, ritonavir or auxiliary components of the drug.
- Severe liver failure.
- Simultaneous use of drugs, whose clearance is significantly dependent on metabolism through the isoenzyme CYP3A.
- Simultaneous use with St. John's wort drugs, boceprevir.
- Simultaneous use of a standard dose of Kaletra with rifampicin.
- Simultaneous use of Caletra and tipranavir with low dose of ritonavir.
- Children under 3 years of age.
- Use of Kaletra once a day in combination with carbamazepine, phenobarbital or phenytoin.
- Use of Kaletra once a day in combination with efavirenz, nevirapine, amprenavir or nelfinavir.
CAUTIOUSLY
- Increased activity of "liver" enzymes.
- Pancreatitis.
- Hemophilia A and B.
- Dislipidemia (hypercholesterolemia, hypertriglyceridemia).
- Older age (over 65 years).
- Patients with organic heart disease, patients with disorders of the cardiac conduction system in their history or patients taking medication that prolongs the PR interval (such as verapamil or atazanavir).
- Simultaneous use with medications for erectile dysfunction, namely sildenafil, tadalafil.
- Simultaneous use with fentanyl, rozuvastatin, atorvastatin, bupropion, glucocorticosteroids inhaled or injected through the nose (e.g. fluticasone, budesonide), antiarrhythmic drugs (e.g. beepridil, lidocaine, quinidine), digoxin, rifampicin, lamotrigin, valproic acid, and others.
- Simultaneous use with medications extending the QT interval
Moderate and severe side effects are given below with frequency (very often ≥1/10; often ≥1/100 but <1/10; not often ≥1/1000 but <1/100).
On the immune system:
Often: hypersensitivity reactions, including hives and angioedema; rarely: immune recovery syndrome.
On the digestive system:
Very often: diarrhoea, nausea, frequent: vomiting, stomach pain (upper and lower parts), gastroenteritis, colitis, dyspepsia, pancreatitis, gastroesophageal reflux, hemorrhoids, flatulence, bloating, hepatitis, hepatomegaly, cholangitis, steatosis of the liver; not often: constipation, stomatitis, oral mucous membrane ulcers, duodenitis, gastritis, gastrointestinal bleeding, including rectal bleeding, dry mouth, gastric and intestinal ulcers, fecal incontinence.
On the nervous system:
Often: headache, migraine, insomnia, neuropathy, peripheral neuropathy, dizziness, anxiety; rarely: agesia, seizures, tremor, cerebrovascular disorders, sleep disturbance, decreased libido.
On the cardiovascular:
Often: arterial hypertension; rarely: atherosclerosis, myocardial infarction, atrioventricular block, triple valve failure, deep vein thrombosis.
On the skin and subcutaneous fatty tissue:
Often: rash, including maculopapulosis, lipodystrophy, including the exhaustion of subcutaneous fat tissue in the face, dermatitis, eczema, seborrhea, increased sweating at night, itching; not often: alopecia, capillary, vasculitis.
On the musculoskeletal:
Often: skeletal-muscular pain, including arthralgia and back pain, myalgia, muscle weakness, muscle spasms; not often: rhabdomyolysis, osteonecrosis.
Metabolic and endocrine system disorders:
Often: hypercholesterolemia, hypertriglyceridemia, weight loss, reduced appetite, diabetes mellitus; not often: weight gain, lactatacidosis, increased appetite, male hypogonadism.
On the kidney and urinary tract:
Often: renal failure; not often: hematuria, nephritis.
On the reproductive system:
Often: erectile dysfunction, amenorrhea, menorrhea.
On sensory organs:
Not often: vestibular dizziness, tinnitus, visual impairment.
Infections:
Very often: upper respiratory tract infections; often: lower respiratory tract infections, skin and subcutaneous fatty tissue infections, including cellulite, folliculitis.
General:
Often: weakness, asthenia.
Changes in laboratory indicators:
Increased concentrations of glucose, uric acid, total cholesterol, total bilirubin, triglycerides, increased serum aspartate transferase (AST) activity, alanine transferase (ALT), gamma-glutamyltranspeptidase (GGTP), lipase, amylase, creatine phosphokines, reduction of inorganic phosphorus, hemoglobin, reduction of creatinine clearance.
Children:
The side effects in children aged 6 months to 12 years were similar to those in adults. Rashes, dysgeusia, vomiting and diarrhoea were the most frequently observed.
- Do not take Kaletra if you are allergic to Lopinavir, Ritonavir, or any ingredients in Kaletra.
- Do not take Kaletra if you take any of the following medicines: alfuzosin; apalutamide; ranolazine; dronedarone; colchicine; rifampin; lurasidone; pimozide; ergot-containing medicines, including dihydroergotamine mesylate, ergotamine tartrate, methylergonovine; cisapride; elbasvir/grazoprevir; lovastatin; simvastatin; lomitapide; sildenafil (REVATIO®), when used for the treatment of pulmonary arterial hypertension; triazolam; midazolam, when taken by mouth; St. John’s Wort (Hypericum perforatum).
- Do not take Kaletra if you have kidney or liver problems.
Keep at a temperature not exceeding 30 °C.
Keep out of the reach of children.Bottle packs: 4 years.
Blister packs: 3 years.
Composition per 1 tab:
Active ingredients: Lopinavir 200 mg, Ritonavir 50 mg.
Auxiliary substances: copovidone K28 - 853.8 mg, sorbitana laurate - 83.9 mg, silicon dioxide colloidal - 12 mg; second layer: sodium stearylfumarate - 12.3 mg, silicon dioxide colloidal - 8 mg.
The composition of the film shell: opadrai colorant red - 22 mg (hypromellose 6 mPa - 58.26%, titanium dioxide - 10.32%, macro-head 400 - 9.03%, hyprolose - 5. 78%, hypromellose 15 mPa - 5.78%, talc - 4.11%, colloidal silicon dioxide - 0.15%, macro-head 3350 - 1.62%, iron dye oxide (E172) - 4.8%, polysorbate 80 - 0.15%).
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