Buy Regulon N21 online.
Pharmacological group:
Estrogens, progestogens; their homologs and antagonists in combinations.
INN:Ethinylestradiol -0.03mg;
desogestrel -0.15mg.
Brand:
Gedeon-Richter.
Regulon tablets - an effective contraceptive. In addition to its direct destination, this drug is prescribed to treat disorders in the menstrual cycle, dysmenorrhea, and dysfunctional bleeding in the uterine cavity. Also, this tool helps to eliminate the symptoms of PMS. The considered contraceptive should not be taken during breastfeeding and during pregnancy.
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Buy Regulon
Regulon is a combined oral contraceptive preparation, the main contraceptive effect of which is to inhibit the synthesis of gonadotropins and suppress ovulation. In addition, by increasing the viscosity of the cervical mucus, the movement of the sperm through the cervical canal is slowed down, and a change in the state of the endometrium prevents implantation of a fertilized egg. Ethinyl estradiol is a synthetic analogue of endogenous estradiol, desogestrel has a pronounced progestogenic and antiestrogenic effect, similar to endogenous progesterone, weak androgenic and anabolic activity. Regulon has a beneficial effect on lipid metabolism - increases the concentration of HDL in the blood plasma, while not affecting the content of LDL. On the background of the use of the drug, there is a significant decrease in the amount of monthly blood loss (with initial menorrhagia), the menstrual cycle is normalized, and there is a beneficial effect on the skin (especially in the presence of acne vulgaris).
Desogestrel
- Suction.
When taken orally, desogestrel is absorbed from the gastrointestinal tract quickly and almost completely. Metabolized to 3-keto-desogestrel, which is the biologically active metabolite of desogestrel. The average Cmax in the serum of 2 ng / ml, Tmax - 1.5 hours after taking the pill. Bioavailability of the drug is 62–81%.
- Distribution.
3-keto-desogestrel binds to plasma proteins, mainly albumin and globulin, which binds sex hormones. Vd is 1.5 l / kg.
- Metabolism.
In addition to 3-keto-desogestrel, which is formed in the liver and intestinal wall, other metabolites are formed: 3α-OH-desogestrel, 3β-OH-desogestrel, 3α-OH-5α-H-desogestrel (1st phase metabolites). They do not possess pharmacological activity and partially, by conjugation (2nd phase of metabolism), are converted into polar metabolites (sulfates and glucuronides). Plasma clearance is about 2 ml / min / kg.
- Derivation.
The average T1 / 2 of 3-keto-desogestrel is 30 hours. Metabolites are excreted by the kidneys and through the intestines (in the ratio 4: 6). Stable concentration is set to the 2nd half of the cycle. At this time, the level of 3-keto-desogestrel increases by 2–3 times.
Ethinylestradiol
- Suction.
Ethinylestradiol is absorbed from the gastrointestinal tract quickly and completely. The average Cmax in serum is 80 pg / ml, Tmax - 1-2 hours after taking the pill. Bioavailability due to presystemic conjugation and first-pass effect is about 60%.
- Distribution.
Ethinylestradiol binds completely to plasma proteins, mainly albumin. Vd is 5 l / kg.
- Metabolism.
Presystemic conjugation of ethinylestradiol is significant. Passing through the intestinal wall (1st phase of metabolism), it undergoes conjugation in the liver (2nd phase of metabolism). Ethinylestradiol and its conjugates of the 1st phase of metabolism (sulfates and glucuronides) are secreted into the bile and enter enterohepatic circulation. Plasma clearance is about 5 ml / min / kg.
- Derivation.
The average T1 / 2 of ethinylestradiol is about 24 hours. About 40% is excreted by the kidneys and about 60% through the intestines. A stable concentration is set by day 3-4, while the level of ethinyl estradiol in serum is 30–40% higher than after a single dose.
- Contraception.
Inside.
Taking pills start from the 1st day of the menstrual cycle and take 1 tab. / Day for 21 days, if possible at the same time of day.
After taking the last tablet out of the package, a 7-day break is taken, during which menstrual-like bleeding occurs due to discontinuation of the drug.
The next day after a 7-day break (4 weeks after taking the 1st tabl., On the same day of the week), taking the drug from the next package, also containing 21 tablets, is resumed, even if the bleeding has not stopped. This pill regimen is followed as long as there is a need for contraception.
When complying with the admission rules, the contraceptive effect is maintained for the duration of the 7-day break.
First dose
Reception 1st tab. should start from the 1st day of the menstrual cycle. In this case, you do not need to use additional methods of contraception. Taking the pills can be started from the 2nd to the 5th day of menstruation, but in this case, in the 1st cycle of using the drug, additional methods of contraception should be applied in the first 7 days of taking the pills. If more than 5 days have passed after the onset of menstruation, you should postpone the start of taking the drug until the next menstruation.
Taking the drug after childbirth
Non-breastfeeding women can start taking the pills no earlier than the 21st day after birth, after consulting a doctor. In this case, there is no need to use other methods of contraception. If you have already had sexual contact after giving birth, then you should wait until the 1st menstruation with the pill. If a decision is made to take the drug later than 21 days after delivery, then in the first 7 days it is necessary to use additional methods of contraception.
Taking the drug after an abortion
After an abortion, in the absence of contraindications, the pill should be started from the 1st day, and in this case there is no need to use additional methods of contraception.
Transfer from another oral contraceptive
Switching to Regulon from another oral medication (21 or 28 days old): 1st tab. Regulon is recommended to be taken the next day after completing a 28-day package of the drug. After completing the 21-day course, you should take a regular 7-day break and then start taking Regulon. No need to use additional methods of contraception.
Switching to Regulon after using oral hormonal preparations containing only progestogen (so-called mini-pili): Table 1. Regulon should be taken on the 1st day of the cycle. No need to use additional methods of contraception. If menstruation does not occur when taking a mini-drink, then after excluding pregnancy, you can start taking Regulon on any day of the cycle, but in this case, additional contraceptive methods should be used in the first 7 days.
In the above cases, the use of the following non-hormonal methods is recommended as an additional method of contraception: the use of a cervical cap with a spermicidal gel, a condom or abstaining from sexual contact. The use of the calendar method in these cases is not recommended.
Delay of the menstrual cycle
If there is a need to postpone menstruation, it is necessary to continue taking pills from a new package, without a 7-day break, in the usual way. With the postponement of menstruation, breakthrough or spot bleeding may appear, but this does not reduce the contraceptive effect of the drug. Regular intake of Regulon can be restored after the usual 7-day break.
Taking missed pills
If a woman forgot to take a pill in a timely manner and after a pass, no more than 12 hours have passed, you just need to take a forgotten pill, and then continue taking it at the usual time. If more than 12 hours have passed between taking the pills, this is considered to be skipping the pill, the reliability of contraception in this cycle is not guaranteed and the use of additional methods of contraception is recommended.
When skipping 1 tab. On the 1st or 2nd week of the cycle, it is necessary to take 2 tab. the next day and then continue regular intake, using additional contraceptive methods until the end of the cycle.
When you skip a pill on the 3rd week of the cycle, you must take a forgotten pill, continue taking it regularly and not take a 7-day break. It is important to remember that due to the minimal dose of estrogen, the risk of ovulation and / or bleeding increases when you skip a pill and therefore it is recommended that additional contraceptive methods be used.
Taking pills for vomiting or diarrhea
If after taking the drug appears vomiting or diarrhea, then the absorption of the drug may be defective. If the symptoms stopped within 12 hours, then 1 more table should be taken. additionally. After that, you should continue taking the pills in the usual way. If symptoms continue for more than 12 hours, it is necessary to use additional methods of contraception during vomiting or diarrhea and in the next 7 days.